16/04/2015 · How to cite this article: Cao, T. et al. Up-regulation of Interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes. Sci. Rep. 6, 25381; doi: 10.1038/srep25381 2016. 03/05/2016 · Psoriasis is a common chronic inflammatory skin disease characterized by epidermal hyperplasia and dermal inflammation. Keratinocyte activation is known to play a critical role in psoriasis, but the underlying mechanism remains unclear. Interferon-inducible protein 16 IFI16, an innate immune system sensor, is reported to affect. 1: Cao T, Shao S, Li B, Jin L, Lei J, Qiao H, Wang G. Up-regulation of Interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes.
Interferon γ-inducible protein 16 IFI16 and cGMP-AMP synthase cGAS have both been proposed to detect herpesviral DNA directly in herpes simplex virus HSV-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two. Keratinocyte activation is known to play a critical role in psoriasis, but the underlying mechanism remains unclear. Interferon-inducible protein 16 IFI16, an innate immune system sensor, is reported to affect keratinocyte function. We therefore hypothesized that IFI16 promotes psoriasis by modulating keratinocyte activation. Moreover, IFI16 up‐regulation is a result of protein accumulation, as expression of corresponding mRNA, assessed by real‐time polymerase chain reaction, was not affected. To investigate the mechanism of IFI16 accumulation, cells were incubated for 6 h in the presence of H 2 O 2 or IFN‐β, and then cycloheximide was added to inhibit further protein synthesis. It’s during the latent phase of EBV that all EBV-associated cancers, including Burkitt’s lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. Interferon-γ-inducible protein 16 IFI16 is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading DNA viruses.
22/08/2014 · interferon γ-inducible protein 16 STING stimulator of interferon genes TBK1 TANK-binding kinase-1 IRF interferon regulatory factor RIG-I retinoic acid-inducible gene I cGAMP cyclic GMP-AMP cGAS cyclic GMP-AMP synthase ISG IFN-stimulated gene ASC apoptosis-associated specklike protein containing a caspase activation and recruitment domain HSV. 12/10/2019 ·; gamma-interferon-inducible protein 16, IFI16 beta isoform, interferon-gamma induced protein IFI 16, interferon-inducible myeloid differentiation transcriptional activator. GeneRIFs: Gene References Into Functions. The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus. 22/08/2014 · The interferon γ-inducible protein 16 IFI16., meaning that type I IFN production leads to the up-regulation of the RIG-I gene. When type I IFN was added to cells, expression levels of RIG-I returned to normal. In contrast, stimulation with Sendai virus did not. IFI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studied in B-CLL as well. Interferon gamma inducible protein 16. A. Robotti, M. de Andrea, G. Gribaudo, et al.Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J. Leukoc. Biol., 77 5 2005, pp. 820-829. Google Scholar.
13/11/2017 · Interferon-γ-inducible protein 16 IFI16 is a multifunctional and ubiquitous host protein, initially found to be constitutively expressed in human lymphoid cells. Since then, IFI16 has been reported to have critical roles in antiviral immunity. 03/07/1998 · Abstract. IFI 16 is a member of a family of interferon-inducible proteins, including the human MNDA myeloid nuclear differentiation antigen, the recently identified AIM-2 absent in melanoma, and the homologous murine molecules, p202, p204, and D3.
Interferon -inducible Protein IFI 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses. 09/03/2011 · IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor protein and other transcription factors. However, the mechanisms of interaction remain unknown. Here, we report the crystal structures of both. Gamma-interferon-inducible protein 16 - Q16666 IF16_HUMAN. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Hydropathy has been calculated using a sliding window of 15 residues and summing up scores from standard hydrophobicity tables. Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by. 22/08/2014 · Interferon γ-inducible Protein IFI 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to.
06/12/2016 · interferon alpha-inducible protein 6, interferon, alpha-inducible protein clone IFI-6-16, interferon-induced protein 6-16. GeneRIFs: Gene References Into Functions. In conclusion, over-expression of IFI6 promotes hepatitis C virus RNA replication and rescues the interferon alpha-mediated anti-hepatitis C virus activity. Up‐regulation of the interferon γ IFN‐γ‐inducible chemokines IFN‐inducible T‐cell α chemoattractant and monokine induced by IFN‐γ and of their receptor CXC receptor 3 in human renal cell carcinoma.
The interferon ␥-inducible protein 16 IFI16 has recently The innate immune system is crucial for regulation of early been linked to the detection of nuclear and cytosolic DNA dur- detection and clearance of invading pathogens. The innate ing infection with herpes simplex virus-1 and HIV. IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor protein and other transcription factors. However, the mechanisms of interaction remain unknown.
Imagine a global collaborative knowledge base for original thoughts. IFI16 - interferon, gamma-inducible protein 16. Homo sapiens. Synonyms: Gamma-interferon-inducible protein 16,. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. This page was last edited on 23 July 2019, at 09:44. All structured data from the main, Property, Lexeme, and EntitySchema namespaces is available under the Creative Commons CC0 L. 147586 - INTERFERON-GAMMA-INDUCIBLE PROTEIN 16; IFI16 - IFI16. The interferons are a family of vertebrate cytokines with pleiotropic activities including antiviral effects, the regulation of cell growth and differentiation, and modulation of immune function. C-X-C motif chemokine 10 CXCL10 also known as Interferon gamma-induced protein 10 IP-10 or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family. P53‐dependent up‐regulation of GBP‐2, an interferon‐inducible gene Several interferon‐inducible genes were found to be differentially expressed at a cut‐off of 2.5‐fold on culture of TE‐1 cells at 32°C. Interferon response pathways are of particular interest given.
However, the role of specific interferon-inducible proteins in cellular senescence remains to be defined. Here we report that IFI 16, an interferon-inducible transcriptional modulator from the p200-protein family, contributes to cellular senescence of prostate epithelial cells. Also functions in TNFSF10-induced apoptosis PubMed:24970806. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors PubMed:22427340. IFI16 A gene on chromosome 1q22 that encodes a member of the HIN-200 haematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats family of cytokines, which contain domains involved in DNA binding, transcription regulation and protein–protein interactions.
Here, we demonstrated that interferon‐inducible protein 16 IFI16 could serve as a unique innate sensor to recognize and bind to HBV cccDNA in hepatic nuclei, leading to the inhibition of cccDNA transcription and HBV replication.
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